Endocannabinoid System Quick Facts

August 25, 2020

The endogenous cannabinoid system, named after the cannabis plant, is perhaps the most important physiologic system involved in establishing and maintaining human health and we only discovered it . Endocannabinoids and their receptors are found throughout the body: in the brain, organs, connective tissues, glands, and immune cells. In each tissue, the cannabinoid system performs different tasks, but the goal is always the same: homeostasis, the maintenance of a stable internal environment despite fluctuations in the external environment. Cannabinoids promote homeostasis at every level of biological life, from the sub-cellular, to the organism, and perhaps to the community and beyond.

Endocannabinoids and cannabinoids are also found at the intersection of the body’s various systems, allowing communication and coordination between different cell types. This may explain why CBD supplements impact a wide range of stressors which prevent us from reaching 100% of our potential. Below are only a few ailments that CBD may have positive results, but it should be mentioned, not all CBD forms and products are the same, so do your research before making a wise purchase.

Appetite Help

CBD helps relieve nausea and can calm your nervous system and digestive tract; therefore, If you feel less nauseated, you may eat more.

Digestion Relief

CBD may be linked to help people with digestive issues. It has been shown to help with the swelling of the stomach and stomach bloating. They are known to help with Irritable Bowel Syndrome as well. CBD helps with gut mobility as well. Gut mobility is the stretching of the gut in the GI tract.

Immune function

The fact that both CB1 and CB2 receptors have been found on immune cells suggests that cannabinoids play an important role in the regulation of the immune system. Considering all the studies conducted on immune responses and inflammation, the data overwhelmingly demonstrate that CBD is immune suppressive and anti-inflammatory.

Inflammation, including neuroinflammation

It is becoming increasingly clear that cannabinoid receptors and their endogenous ligands play a crucial role in the regulation of the immune system. Exogenous cannabinoids have been shown to suppress T-cell-mediated immune responses by primarily inducing apoptosis and suppressing inflammatory cytokines and chemokines.  As CB2 receptors are primarily expressed on immune cells, targeting CB2 may result in selective immunomodulation without overt toxicity.

Maximize Mood

Most antidepressant medications take weeks to start working. However, a 2019 animal study  found that CBD has a fast and sustained antidepressant-like effect. CBD may also result in fewer side effects than antidepressant medication. Insomnia, sexual dysfunction, mood swings, and agitation are common side effects of antidepressants. CBD has not shown similar issues.

Sleep Deeply

Some research indicates that the cannabinoid CBD may interact with specific receptors, potentially affecting the sleep/wake cycle. Additionally, CBD may also decrease anxiety and pain, which can both interfere with restful sleep. By reducing certain symptoms, it’s also possible that sleep may improve.

Blood Pressure

Studies indicate that CBD may be able to help with high blood pressure. One recent study treated nine healthy men with one dose of 600 mg of CBD oil and found it reduced resting blood pressure, compared to a placebo. The same study also gave the men stress tests that normally increase blood pressure. Interestingly, the single dose of CBD led the men to experience a smaller blood pressure increase than normal in response to these tests.

Temperature regulation

CBD activates several receptors and ion channels, including vanilloid receptors (which control body temperature, inflammation, and the ability to feel pain), and others, especially when taken in high concentrations.

Improve Memory

Memory loss produced by degenerative diseases, such as dementia and Alzheimer’s, is yet another area that CBD oil has been shown to have a positive impact. CBD oil has the ability to aid in the regeneration of neurons, reduce inflammation, and act as an antioxidant, all of which contribute to improved cognitive function.

Relieve Pain Pain

Animal studies have suggested that CBD has pain-relieving and anti-inflammatory properties, but these effects have not been validated in quality studies in humans. Anecdotally, some people with arthritis who have tried CBD, but not all, report noticeable pain relief, sleep improvement and/or anxiety reduction.

Neurological Disorders

Researchers believe that CBD’s ability to act on the endocannabinoid system and other brain signaling systems may provide benefits for those with neurological disorders. In fact, one of the most studied uses for CBD is in treating neurological disorders like epilepsy and multiple sclerosis. Though research in this area is still relatively new, several studies have shown promising results.

Crohn's Disease

After one two month study, researchers said the participants given cannabis oil experienced a significant improvement in their Crohn’s disease symptoms and quality of life. About 65 percent of the cannabis oil group strictly met the criteria for a full remission of symptoms, while 35 percent of the placebo group did.

  • https://www.sleepassociation.org/sleep-treatments/cbd/
  • https://usa.inquirer.net/31501/cbd-oil-benefits-the-best-cbd-oil-digestive-aid#:~:text=CBD%20and%20Digestion,Irritable%20Bowel%20Syndrome%20as%20well.
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5665515/#:~:text=Cannabis%20spp.,uses%20of%20its%20derived%20products.&text=Hemp%20seeds%20produce%20negligible%2C%20if%20any%2C%20quantities%20of%20THC%20endogenously.
  • https://norml.org/marijuana/library/recent-medical-marijuana-research/introduction-to-the-endocannabinoid-system/
  • https://www.verywellhealth.com/what-is-the-endocannabinoid-system-4171855
  • https://usa.inquirer.net/31501/cbd-oil-benefits-the-best-cbd-oil-digestive-aid#:~:text=CBD%20and%20Digestion,Irritable%20Bowel%20Syndrome%20as%20well.
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7173676/
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828614/
  • https://www.healthline.com/health/cbd-for-depression#cbd-vs-antidepressants
  • https://www.civilized.life/articles/what-cbd-does-to-body/
  • https://www.ncbi.nlm.nih.gov/pubmed/29869197
  • https://www.healthline.com/health-news/cannabis-improves-symptoms-of-crohns-disease
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